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  • Non-Invasive Strategies for Nose-to-Brain Drug Delivery - PMC
    Nose-to-brain delivery pathways The target region for effective nose-to-brain drug delivery is the olfactory epithelium in the upper nasal cavity This region contains olfactory nerve cells which bypass the BBB provide direct access to the brain CSF
  • On a highway to the brain: A review on nose-to-brain drug . . .
    In this sense, there is an urgent need for high-resolution imaging methods to follow nanomedicines distribution from the nasal cavity to the brain and differentiate their localization among intravascular, extracellular (perineural and perivascular), and intracellular (neuronal and glial) sites
  • Potential Targeting Sites to the Brain Through Nasal Passage
    Consequently, nose-to-brain delivery has been explored as a feasible drug delivery route to the brain utilizing the nasal passages and tissue This delivery pathway allows for simplified administration, a fast onset of action, patient compliance and a reduced systemic exposure of the delivered agent [ 4 , 13 , 14 ]
  • Nose-to-Brain Delivery - The Journal of Pharmacology and . . .
    One way to bypass the blood brain barrier and thus treat diseases of the brain is to use the nasal route of administration and deposit drugs at the olfactory region of the nares, from where they travel to the brain via mechanisms that are still not clearly understood, with travel across nerve fibers and travel via a perivascular pathway both
  • The Nasal–Brain Drug Delivery Route: Mechanisms and . . .
    Nose-to-brain delivery offers significant benefits such as noninvasiveness, rapid action, CNS specificity, minimal side effects, and ease of self-administration due to the nasal vasculature network and high permeability of nasal epithelia, bypassing first-pass metabolism [8, 9]
  • Nasal airflow and brain activity: is there a link?
    It seems that a nasal airflow stimulus may have an activating effect on the brain, as it has also been shown to trigger seizure activity in epileptic patients This article explores these theories in detail, reviews the evidence, and presents new models linking nasal airflow and brain activity





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