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  • Effects of Intensive Diet and Exercise on Knee Joint Loads . . .
    To determine the effects of weight loss on patients with knee osteoarthritis, Messier and coauthors conducted a 18-month randomized clinical trial comparing 3 interventions—intensive diet-induced weight loss plus exercise, intensive diet-induced weight loss, and exercise—among 454 overweight and
  • Effects of intensive diet and exercise on knee joint loads . . . - PubMed
    Abstract Importance: Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity Objective: To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than exercise alone
  • Effects of intensive diet and exercise on knee joint loads . . .
    Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
  • Effects of intensive diet and exercise on knee joint loads . . .
    Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial JAMA 2013 Sep 25;310 (310) 1263-73 PMID: 24065013 [PubMed] PMCID: PMC4450354 NIHMSID: NIHMS683339
  • September 25, 2013 Issue of JAMA
    To determine the effects of weight loss on patients with knee osteoarthritis, Messier and coauthors conducted a 18-month randomized clinical trial comparing 3 interventions—intensive diet-induced weight loss plus exercise, intensive diet-induced weight loss, and exercise—among 454 overweight and obese older community-dwelling adults
  • Effects of intensive diet and exercise on knee joint loads . . .
    has subject area Aged Biomarkers Biomechanical Phenomena Body Mass Index Diet, Reducing Exercise Therapy Female Humans Inflammation Interleukin-6 Male Middle Aged Obesity Osteoarthritis, Knee Overweight Pain Measurement Quality of Life Self Report Single-Blind Method Treatment Outcome Weight Loss Weight-Bearing
  • Effects of Intensive Diet and Exercise on Knee Joint Loads . . .
    IMPORTANCE Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity OBJECTIVE To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than exercise alone DESIGN, SETTING, AND PARTICIPANTS Single-blind, 18-month
  • Effects of intensive diet and exercise on knee joint loads . . .
    Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial JAMA 2013 Sep 25;310 (12):1263-73 doi: 10 1001 jama 2013 277669 ICH GCP
  • The effects of intensive dietary weight loss and exercise on gait in . . .
    The Intensive Diet and Exercise for Arthritis (IDEA) trial was an 18-month randomized controlled trial that enrolled 454 overweight and obese older adults with symptomatic and radiographic knee osteoarthritis (OA) Participants were randomized to
  • The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month . . .
    Report the radiographic and magnetic resonance imaging (MRI) structural outcomes of an 18-month study of diet-induced weight loss, with or without exercise, compared to exercise alone in older, overweight and obese adults with symptomatic knee osteoarthritis (OA)





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