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  • GV-971 | ALZFORUM
    GV-971 reportedly also reduced brain Aβ burden, tau hyperphosphorylation, and cognitive deficits in these mice This paper was subsequently challenged as a matter arising in the same journal (Rao, 2020) and on the online journal club website PubPeer
  • Effect of 1 night of total sleep deprivation on . . . - ALZFORUM
    Ooms S, Overeem S, Besse K, Rikkert MO, Verbeek M, Claassen JA Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial JAMA Neurol 2014 Aug;71 (8):971-7 PubMed
  • Therapeutics Search | ALZFORUM
    NSC001 50561 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-1088 ABBV-552 ABBV-916 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24 060 ACI-3024 ACI-7104 056 Acitretin ACP-204 AD04 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 AL003 AL044 AL101 ALIA-1758 Allopregnanolone ALN-5288 Alpha
  • Therapeutics - ALZFORUM
    AD Target Therapy Types The two tables below organize the therapeutics within this database by therapy type and proposed target type The number of therapeutics within each category is indicated according to the highest phase each therapeutic has achieved in U S clinical trials For example, if a given therapeutic is in both Phase 2 and Phase 3 trials, it is included in the Phase 3 total
  • APP+PS1 - ALZFORUM
    APP+PS1 transgenic rats express human APP with the Swedish and Indiana mutations and human PSEN1 with the L166P mutation Both transgenes are driven by the ubiquitin-C promoter These rats exhibit amyloid pathology, neurodegeneration, and behavioral deficits To generate this line, a lentivral
  • Mouse neuroblastoma cells release prion infectivity associated with . . .
    Alais S, Simoes S, Baas D, Lehmann S, Raposo G, Darlix JL, Leblanc P Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles Biol Cell 2008 Oct;100 (10):603-15 PubMed
  • BT-267 | ALZFORUM
    Background BT-267 is a selective, brain-penetrant small molecule inhibitor of leucine-rich repeat kinase LRRK2 It is designed to maximize CNS exposure and minimize peripheral activity, to reduce off-target and systemic effects It is being developed to treat Parkinson’s disease
  • SAR446159 | ALZFORUM
    Background SAR446159 is an IgG monoclonal antibody to α-synuclein, with an insulin-like growth factor receptor (IGF1R) binding domain acting as a shuttle to transport it across the blood-brain barrier The shuttle platform was invented at ABL Bio, and the antibody is being developed in collaboration with Sanofi
  • Engensis - ALZFORUM
    Engensis delivers HGF to muscle, not the central nervous system Injection of the plasmid into the hind limb muscles of rabbits or mice caused detectable HGF expression for about two weeks, with peak protein production after seven days (Pyun et al , 2010) No preclinical data on this DNA construct in ALS models are published However, an adenovirus vector version with the same HGF coding
  • Iclepertin - ALZFORUM
    Clin Ther 2019 May;41 (5):961-971 Epub 2019 Apr 17 PubMed Wunderlich G, Blahova Z, Garcia M, Jessen F Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer's dementia: a randomized controlled trial Alzheimers Res Ther 2023 Jan 28;15 (1):24 PubMed





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