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  • U-18666A - Cell Signaling Technology
    U-18666A is a cell permeable drug that inhibits cholesterol transport This small molecule inhibits low density lipoprotein (LDL)-derived cholesterol transport, blocking cholesterol esterification, and suppressing LDL receptor activities (1)
  • Identification of NPC1 as the target of U18666A, an inhibitor of . . .
    Cholesterol export is inhibited by nanomolar concentrations of U18666A, a cationic sterol To identify the target of U18666A, we synthesized U-X, a U18666A derivative with a benzophenone that permits ultraviolet-induced crosslinking When added to CHO cells, U-X crosslinked to NPC1
  • U18666A | Cholesterol Transport Inhibitor | MedChemExpress
    U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus For research use only We do not sell to patients
  • The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the . . .
    Use of the MVB (multivesicular body) inhibitor U18666A enabled a detailed analysis of the impact of MVBs for viral morphogenesis and release It was revealed that infectious, fully assembled HCV particles are either MVB-dependently released or intracellularly degraded by the lysosome
  • U18666A, an intra-cellular cholesterol transport inhibitor, inhibits . . .
    U18666A is an amphipathic steroid 3-β- [2- (diethylamine)ethoxy]androst-5-en-17-one It is a widely used chemical to block the intracellular trafficking of cholesterol and mimic Niemann-Pick type C disease, a hereditary lysosomal storage disease
  • Potential Use of the Cholesterol Transfer Inhibitor U18666A . . . - Springer
    U18666A inhibits the capacity of cholesterol derived from LDL to promote cholesterol esterification, as well as the activities of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and LDL receptors
  • U 18666A powder 3039-71-2 - MilliporeSigma
    Biochem physiol Actions Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase) Weak inhibitor of hedgehog (hh) signaling U18666A, a Niemann-Pick phenotype inducer [5], can inhibit the lysosomal cholesterol export and Ebola infection [1]
  • U18666A | 99. 91% (HPLC) | In Stock | Antiviral inhibitor
    U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication Viral particles are trapped in the Lamp-1 positive late endosome lysosome compartment when cells are treated with U18666A In addition, viral replication is also affected by U18666A treatment
  • The Compound U18666A Inhibits the Intoxication of Cells by
    In the current study, we demonstrate that intoxication by TcdA and TcdB is diminished in cultured cells preincubated with the compound U18666A, an established inhibitor of cholesterol biosynthesis and or intracellular transport





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