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  • Cancer Immunotherapy, Part 3: Challenges and Future Trends
    INTRODUCTION During the past few decades, research has provided breakthroughs that have enhanced our understanding of the mechanisms and pathways that regulate the immune system’s response to cancer 1 However, despite these advances, obstacles still exist for the field of cancer immunotherapy 1 These include the inability to predict treatment efficacy and patient response; the need for
  • Cancer immunotherapy: Challenges and limitations - ScienceDirect
    Tumor heterogeneity is one of the major challenges that are faced in terms of response to immunotherapy Major sources of tumor heterogeneity include differences in somatic mutations in specific oncogene pathways between cancers of individual patients and also environmental factors such as the composition of the gut microbiome [153]
  • Top 10 Challenges in Cancer Immunotherapy - PubMed
    Here, we define ten key challenges facing cancer immunotherapy, which range from lack of confidence in translating pre-clinical findings to identifying optimal combinations of immune-based therapies for any given patient Addressing these challenges will require the combined efforts of basic researchers and clinicians, and the focusing of
  • Addressing current challenges in cancer immunotherapy with . . .
    2 The major challenges for cancer immunotherapy A tumour can, in principle, be recognized and controlled by the patient's immune system via a coordinated process that has recently been summarized as the ‘cancer-immunity’ cycle []
  • Five key factors predict the response of cancer patients to . . .
    The results suggest that patients with certain types of tumours, who are currently not considered candidates for immunotherapy (such as those with liver or kidney carcinomas) might benefit from
  • Scientists Identify 5 Key Factors That Predict Cancer . . .
    Immunotherapy has revolutionized cancer treatment by harnessing the immune system to target tumor cells However, only 20-40% of patients show a positive response, with these rates differing depending on the type of cancer Identifying which patients will benefit from immunotherapy is a major focus of ongoing research
  • Cancer immunotherapy: it’s time to better predict patients . . .
    Prelaj et al 113 have described a novel score (EPSILoN), which could help to identify patients with NSCLC who are most likely to benefit from second-line immunotherapy This prognostic score combines several clinical (smoking and liver metastases) and blood parameters (LDH level and neutrophil lymphocyte ratio)





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