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  • A review of the mechanism of the central analgesic effect of . . .
    Lidocaine can block Na + and K + ion channels and regulate intracellular and extracellular calcium concentrations through other ligand-gated ion channels Lidocaine was the first sodium channel blocker to be identified Its main mechanism of action is blocking voltage-gated Na + channels (VGSC NaVs)
  • Lidocaine - StatPearls - NCBI Bookshelf
    Lidocaine can also be administered intravenously during tracheal intubation, obtunding the hypertensive response to laryngoscopy and potentially reducing the incidence of myalgia and hyperkalemia after succinylcholine is given
  • Lidocaine administration techniques for head and limb wound . . .
    Patients with topical lidocaine reported higher starting pain, while those receiving subcutaneous lidocaine experienced significantly more pain during administration and suturing (P < 0 05), highlighting the impact of lidocaine application methods on patient pain experiences
  • Using Lidocaine to Manage Wounds - WoundSource
    One of the main benefits of lidocaine is its rapid onset of action; while stronger or longer-acting substances may be preferred for surgical procedures, lidocaine’s fast-acting nature makes it perfect for reducing pain in a wound Lidocaine has been my go-to product for wound care for over 20 years
  • Lidocaine Infusion: Applications and Mechanisms Explained
    Lidocaine infusions have beneficial effects when applied perioperatively, potentially leading to reduced opioid requirements post-surgery Studies suggest that lidocaine can be administered safely in outpatient settings, highlighting its flexibility and practicality in clinical practice
  • Molecular mechanisms of action of systemic lidocaine in acute . . .
    In most studies, an initial bolus of 1e2 mg kg 1 was administered, followed by continuous infusion of 2e4 mg kg 1 h 1, resulting in plasma concentrations of 1e3 mg ml 1 (z4e13 mM) 9e16 Furthermore, clinical studies have shown the efficacy of lidocaine in patients suffering from chronic neuropathic pain
  • Intravenous Lidocaine for Management of Wound Care Pain
    Lidocaine 125 mg infused intravenously over 30 minutes at the time of dressing changes provided effective pain relief The patient also reported that his chronic back pain improved after initiation of lidocaine therapy





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