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  • Pathology Outlines - Clear cell meningioma
    Answer C is incorrect because although clear cell meningioma can show concerning features such as mitoses and necrosis, it is classified as CNS WHO grade 2, not grade 3 Answer D is incorrect because a desmoplastic reaction with abundant collagen is more typical of fibroblastic or transitional meningiomas (WHO grade 1)
  • Pathology Outlines - WHO grading of meningiomas
    Molecular characteristics now part of the classification for anaplastic (malignant) meningioma, CNS WHO grade 3: TERT promotor mutation (Brain Pathol 2014;24:184, Oncotarget 2017;8:109228) CDKN2A B homozygous deletion (Am J Pathol 2001;159:661, Brain Pathol 2002;12:183, Acta Neuropathol 2020;140:409)
  • Pathology Outlines - Chordoid meningioma
    Chordoid meningioma is a histological subtype of meningioma characterized by cords or trabeculae of epithelioid (or spindle) cells embedded in a mucin rich stroma and resembling chordoma It is classified as CNS WHO grade 2, regardless of the presence of worrisome histological features (mitoses, spontaneous necrosis, brain invasion)
  • Pathology Outlines - Ectopic meningioma
    Like primary intracranial meningioma, tumor grade and extent of surgical resection are the most important prognostic factors for ectopic meningioma In general, ectopic meningioma of the head and neck tends to show a higher recurrence rate due to complex anatomy and difficulty in obtaining complete surgical resection ( Ear Nose Throat J 2022;101:NP383 )
  • Pathology Outlines - Solitary fibrous tumor
    (Fibrous) meningioma (closest histologic mimic): STAT6-, EMA+, SSTR2A+ Often shows psammoma bodies calcifications, which are not seen in solitary fibrous tumor Dural Ewing sarcoma: STAT6-, evidence of EWSR1 rearrangement Synovial sarcoma: EMA+, TLE1+, evidence of SS18 rearrangement Malignant peripheral nerve sheath tumor:
  • Pathology Outlines - Atypical meningioma
    The image shows an atypical meningioma with small cell change, characterized by reduced cytoplasm and increased N C ratio in these regions These regions may resemble lymphoplasmacytic inflammation on low power but on high power show nuclei that are similar to adjacent tumor cells Comment Here Reference: Atypical meningioma
  • Pathology Outlines - SSTR2A
    Independent predictor of improved overall survival and progression free survival in neuroendocrine tumors (NET) (Pancreas 2016;45:1386, Eur J Nucl Med Mol Imaging 2017;44:468, Medicine (Baltimore) 2015;94:e1281)
  • Pathology Outlines - Epithelial membrane antigen (EMA)
    CD34 is better for differentiating solitary fibrous tumors from meningioma and is typically negative in schwannoma MelanA differentiates meningioma from melanoma MelanA is negative in most schwannomas S100 can be positive in both schwannoma and in fibrous meningioma (J Neuropathol Exp Neurol 2017;76:289) Comment Here
  • Pathology Outlines - Papillary meningioma
    19 year old man with spinal papillary meningioma (Acta Neurochir (Wien) 2000;142:703) 25 year old woman with jugular foramen papillary meningioma (Brain Tumor Pathol 2004;21:143) 29 year old woman with meningioma with rhabdoid, papillary and clear cell features (Clin Neuropathol 2011;30:291)
  • Pathology Outlines - Rhabdoid meningioma
    Stout processes consistent with meningioma; however distinct cell borders Often vesicular nuclei with prominent nucleoli May see mitoses on smear May see pseudonuclear inclusions (Diagn Cytopathol 2010;38:594)





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