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  • Advancements in Clinical Utilization of Recombinant Human Collagen: An . . .
    Innovation in drug delivery systems has expanded recombinant collagen’s utility in dermatological applications Microneedle patches integrating recombinant human collagen enhance transdermal drug delivery by improving therapeutic absorption while minimizing skin irritation
  • An Update on the Clinical Efficacy and Safety of Collagen Injectables . . .
    In particular, severe adverse events were addressed to the use of one collagen-based product that was Augment ®, an injectable formulation composed of bovine collagen, β-tricalcium phosphate and recombinant human platelet-derived growth factor-BB (NCT01305356, NCT00583375)
  • Transdermal transport of collagen and hyaluronic acid using water in . . .
    Here, we evaluated the transdermal penetration of low and high molecular weight collagen and HA from microemulsions A number of microemulsion formulations, differing in the content of polymers and surfactants (i e penetration promoters), were used for the permeation study
  • Collagen: A Review of Clinical Use and Efficacy
    Orally administered collagen in its many different forms is recognised as a highly biocompatible, safe form of supplementation, which has the potential to act on the body as an anti-inflammatory and antioxidant, and through structural remodelling and reduced lipotoxicity
  • Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone . . .
    Collagen makes up a large proportion of the human body, particularly the skin As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system
  • Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening . . .
    Frequent exposure to ultraviolet (UV) radiation [2] and unhealthy lifestyle habits such as lack of sleep, smoking, and excessive alcohol consumption can accelerate collagen degradation The use of anti-aging and moisturizing skincare products is crucial to combat this
  • A regulatory perspective on recombinant collagen-based medical . . . - PubMed
    The regulatory review of recombinant collagen-based medical devices aims to assess their safety and efficacy demonstrated by scientific evidences generated from preclinical and clinical evaluations
  • A REVIEW ON COLLAGEN BASED DRUG DELIVERY SYSTEMS - IJRPB
    Due to its biodegradability, biocompatibility, weak antigenicity and well-known safety profile, collagen becomes a very useful carrier for the delivery of various kinds of drugs and agents like growth factors, collagen possess some very unique properties as compare to other drug carriers that’s why a numerous number of researches are in pipeline
  • In vivo Visualization of Collagen Transdermal Absorption by Second . . .
    In this study, we used a novel noninvasive approach to dynamically capture the process of collagen transdermal absorption in vivo by combining SHG with TPEF Both two-photon fluorescence imaging and second harmonic imaging are second-order nonlinear processes
  • An Update on the Clinical Efficacy and Safety of Collagen . . . - MDPI
    In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital
  • Transdermal Delivery of Functional Collagen Via . . . - PubMed
    This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w w)
  • Three Decades of Research on Recombinant Collagens: Reinventing the . . .
    While in the fibril-forming collagens, including types I, II, and III, the Gly-X-Y triplets form uninterrupted repeats, in other collagen types, including types IV, VII, and IX, stretches of amino acid sequences without the Gly-X-Y pattern interrupt the Gly-X-Y repeats
  • Collagen-Based Dissolving Microneedles with Flexible Pedestals: A . . .
    Biocompatible polymer microneedles (MNs) are emerging as a promising platform for transdermal drug delivery, especially for facial treatments Therefore, an MN patch in this study uses hydrolyzed collagen (HC) contained in skin cells as the main raw material and adopts a two-step cast method to deve …
  • Collagen Hydrolysates for Skin Protection: Oral Administration and . . .
    Oral ingestion of HC increases the levels of collagen-derived peptides in the blood torrent and improves the skin properties such as elasticity, skin moisture, and transepidermal water loss Additionally, daily intakes of HC protect the skin against UV melasma, enhances the fibroblast production and extracellular matrix of the skin
  • An Update on the Clinical Efficacy and Safety of Collagen Injectables . . .
    In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital





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