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  • β地中海贫血模型——Hbb-bs Hbb-bt DKO小鼠 - Cyagen
    Hbb-bs Hbb-bt DKO小鼠是利用基因编辑技术同时敲除C57BL 6J小鼠Hbb-bs基因和Hbb-bt基因所构建的β地中海贫血疾病模型。 该模型纯合致死，杂合小鼠呈现血红蛋白含量、红细胞计数、红细胞压积、平均红细胞血红蛋白浓度、红细胞分布宽度、血小板数、脾脏大小和红细胞形态等指标异常的严重地中海贫血典型特征并具有生育能力。 因此，杂合Hbb-bs Hbb-bt DKO小鼠可用于与β地中海贫血相关的研究。 (1)生长曲线 图1 杂合Hbb-bs Hbb-bt DKO小鼠和野生型（WT）小鼠的体重变化曲线，雌性和雄性杂合Hbb-bs Hbb-bt DKO小鼠均呈现和野生型小鼠较为一致的生长状况。
  • Hbb-bs小鼠基因|Hbb-bs基因功能|Hbb-bs小鼠模型-RDDC官网
    Hbb-bs基因编码成人血红蛋白β多肽链，负责氧气输送。 页面提供物种序列比对、转录本、蛋白质互作、表达量及模型研究数据，支持罕见疾病研究。 首页
  • Mouse Gene Hbb-bt (ENSMUST00000098192. 4) from GENCODE VM37
    Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits For more distant species reciprocal-best BLASTP hits are used Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene
  • Hbb-bs hemoglobin, beta adult s chain [Mus musculus (house mouse . . .
    ENU mutagenesis generated mouse lines with dominant beta-thalassemia mutations resembling those in the human disease: a nonsense mutation at codon 40 in exon 2 and a mutation at the polyadenylation signal of the beta-major gene
  • Ancestral β-globin gene haplotypes modify β-thalassemia severity in a . . .
    The Hbb single haplotype, normally found in C57BL 6 mice, contains Hbb-bs and Hbb-bt, which encode identical β-globin proteins The diffuse haplotype, found in 129 and BALB c strains, contains Hbb-b1 and Hbb-b2, which encode proteins that differ from each other and from β-globin single ( supplemental Figure 1 B-C)
  • 血红蛋白β亚基（HBB）基因 | MCE - MCE-生物活性分子大师
    血红蛋白β亚基： α (HBA) 和β (HBB) 位点决定了成人血红蛋白 Hb A 中两种多肽链的结构。 正常的成人血红蛋白四聚体由两条 α 链和两条 β 链组成。 突变的 β 珠蛋白会导致镰状细胞性贫血。
  • Mutational analysis of hemoglobin genes and functional characterization . . .
    Thalassemia is one of the most prevalent genetic disorders worldwide The present study aimed to explore the mutational spectrum of all hemoglobin (HB) encoding genes and to identify the
  • Identification of seven novel variants in the β-globin gene in . . .
    β-Globin protein (HBB), one of the hemoglobin subunits, is produced by β-globin gene (HBB), which is located on chromosome 11 [1] Two β-globin molecules bind to two α-globin molecules to constitute the most popular form of hemoglobin, adult hemoglobin (HbA)
  • Hemoglobin, beta Adult Major Chain Proteins
    Compare Order Hemoglobin, beta Adult Major Chain Proteins from many different species Find the right product on antibodies-online com





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