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  • JULIE GREEN MINISTRIES
    Julie Green Ministries exists to transform lives through God’s unconditional love, His Word, and the hope that comes from a personal relationship with Him JGM is broadening our reach by participating in various social media platforms! You can now find us on:
  • Julie Green Ministries International | Davenport IA - Facebook
    Julie Green Ministries International was live Jesus has redeemed you from the curse and has set you free Declare and decree your freedom Satan wants to bring you back into a slave mentality, but you have already been set free Unforgiveness poisons your spirit and soul Let go of your unforgiveness Get into the presence of the Lord
  • Structural Basis for Target-Directed MicroRNA Degradation
    Here, we report structures of human Ago2 (hAgo2) bound to miRNAs and TDMD-inducing targets miRNA and target form a bipartite duplex with an unpaired flexible linker hAgo2 cannot physically accommodate the RNA, causing the duplex to bend at the linker and display the miRNA 3′ end for enzymatic attack
  • TDMD — Kleaveland Lab
    One way to degrade miRNAs is through target-directed miRNA degradation (TDMD), a phenomenon first observed with synthetic and viral RNAs containing highly complementary binding sites to a miRNA More recently, several endogenous RNAs that trigger TDMD have been described
  • Target RNA-directed microRNA degradation; which controls . . .
    TDMD in general models and in miR-30 serpine1 RNA duplex miRNAs control target gene expression by inhibiting translation and target RNA degradation
  • SnapShot: Target-directed miRNA degradation - PubMed
    MicroRNAs (miRNAs) guide Argonaute (AGO) proteins to bind and repress target RNAs However, some unusual targets trigger destruction of the miRNA, a phenomenon known as target-directed miRNA degradation (TDMD)
  • Target-directed microRNA degradation: Mechanisms . . .
    Recently, it was revealed that certain targets, so-called target-directed miRNA degradation (TDMD) triggers, can “trigger” miRNA decay through inducing proteolysis of AGO and thereby the bound miRNA This process is mediated in animals via the ZSWIM8 ubiquitin ligase complex, which is recruited to AGO during engagement with triggers
  • SnapShot: Target-directed miRNA degradation - Cell Press
    MicroRNAs (miRNAs) guide Argonaute (AGO) proteins to bind and repress target RNAs However, some unusual targets trigger destruction of the miRNA, a phenomenon known as target-directed miRNA degradation (TDMD)


















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