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  • PRAME - Wikipedia
    PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene [3] [4] [5] Five alternatively spliced transcript variants encoding the same protein have been observed for this gene [5]
  • PRAME Expression in Melanocytic Tumors - PMC - PubMed Central (PMC)
    PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is
  • PRAME Expression in Melanocytic Tumors - PubMed
    In this study we examined the immunohistochemical expression of PRAME in 400 melanocytic tumors, including 155 primary and 100 metastatic melanomas, and 145 melanocytic nevi Diffuse nuclear immunoreactivity for PRAME was found in 87% of metastatic and 83 2% of primary melanomas
  • Pathology Outlines - PRAME
    PRAME (preferentially expressed antigen in melanoma) is a cancer testis antigen expressed by melanoma and other malignant neoplasms with expression in normal tissue largely restricted to testis
  • PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in . . . - MDPI
    PRAME is a nuclear receptor, a transcriptional regulator, and a member of the cancer testis antigen (CTA) family of proteins It is situated on the reverse strand of chromosome 22 (22q11 22), within the human immunoglobulin lambda gene locus
  • Use of the Pigmented Lesion Assay to rapidly screen a patient with . . .
    The Pigmented Lesion Assay (PLA) (DermTech, La Jolla, CA) involves tape-stripping lesions to obtain stratum corneum from which RNA is isolated and expression levels of the noncoding long RNA Linc00518 (Linc) and PRAME genes are assessed 2 Lesions showing elevated expression levels of both Linc and PRAME, either Linc or PRAME, or neither gene
  • Clinicopathological and Prognostic Significance of PRAME Overexpression . . .
    Preferentially expressed antigen in melanoma (PRAME) is one of the most immunogenic CTAs discovered to date The PRAME protein was first described as a tumour antigen in human melanoma by Ikeda et al [5]
  • PRAME – MyPathologyReport
    PRAME stands for “preferentially expressed antigen in melanoma ” It is a special type of protein called a cancer-testis antigen This means that PRAME is usually found in cancer cells and normal cells within the testis, but rarely in other normal tissues of the body
  • PRAME expression and clinical outcome of breast cancer
    The tumour antigen PReferentially expressed Antigen of MElanoma (PRAME) is expressed in a variety of malignancies, including breast cancer We have analysed PRAME gene expression in relation to clinical outcome for 295 primary breast cancer
  • EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial . . .
    We provide evidence that PRAME modulates retinoic acid (RA) signaling, forming a ternary complex with the RA receptor α (RARα) and the Enhancer of Zeste Homolog 2 (EZH2) Knockdown of PRAME





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