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  • Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells . . .
    This review describes the role of FAP in the TME and its potential as a target in CAR-T cell immunotherapy, summarizes the preclinical studies and clinical trials of anti-FAP-CAR-T cells to date, and reviews possible optimizations to augment their cytotoxic efficiency in solid tumors
  • From basic research to clinical application: targeting . . .
    FAP's intricate interactions with tumor cells and the tumor microenvironment make it a promising target for diagnosis and treatment Promising strategies such as FAPI offer potential avenues for accurate tumor diagnosis, while multiple therapeutic strategies highlight the prospects of FAP targeting …
  • Antitumor efficacy and potential mechanism of FAP-targeted . . .
    FAP plays a notable role in promoting tumor growth, migration, and progression, with its overexpression being linked to poor prognosis in certain cancers Thus, FAP-targeting radiopharmaceuticals
  • Targeting fibroblast activation protein (FAP): advances in . . .
    Here, we try to review and highlight the recent advances in immunotherapies for FAP targeting including the anti-FAP antibodies and immunoconjugates, FAP chimeric antigen receptor (CAR)-T cell, and various FAP vaccines in a preclinical and clinical setting
  • Targeting FAP in Cancer: A Promising Therapeutic Approach
    One potential breakthrough lies in targeting Fibroblast Activation Protein (FAP), a protein that plays a key role in tumor progression, metastasis, and resistance to treatments
  • Fibroblast Activation Protein (FAP)-a promising target for . . .
    FAP-targeting CAR-T cells have been genetically engineered to target CAFs in various solid cancers, such as mesothelioma, lung and pancreatic cancers Clinical trials are in early stages Examples: Prodrugs are inactive medications that chemicals or enzymes provide targeting by their activation after the medication enters the body 2
  • Radioligands Targeting Fibroblast Activation Protein (FAP)
    By the choice of an appropriate radionuclide, FAP-targeted tracers can be used for imaging or therapy in many cancer types Therefore, the first successful application of FAP-targeted imaging has led to an enormous and growing interest in nuclear medicine and radiopharmacy





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