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  • Mechanisms and inhibition of HIV integration - PMC
    HIV integrase is required for viral replication and a rationale target for antiretroviral therapies Integrase inhibitors are potentially complementary to current treatments This review focuses on the mechanisms of HIV integration The roles of
  • The role of integration and clonal expansion in HIV infection . . .
    Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that persist during combination antiretroviral therapy (cART) Cells with replication competent HIV proviruses form a reservoir that persists despite
  • Nuclear landscape of HIV-1 infection and integration
    Targeting HIV-1 integration is one of the most compelling therapeutic tasks: drugs that target the integrase of HIV-1, such as raltegravir or its variants, or those that interfere with the
  • Recent advances in the development of integrase inhibitors . . .
    Hence, targeting integration is not only expected to block HIV replication but may also reveal new therapeutic strategies to treat HIV as well as other retrovirus infections Recent findings HIV integrase (IN) has gained attention as the most promising therapeutic target as there are no equivalent homologues of IN that has been discovered in
  • Emerging role of integrase inhibitors in the management of . . .
    Mechanism of action for integrase inhibition Integrase is an HIV-1 enzyme that is essential for viral replication Integrase catalyzes at least 3 reactions: 3′ processing, formation of the preintegrase complex, and strand transfer (Figure 2)
  • Retroviral Integrase: Structure, Mechanism, and Inhibition
    Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M, Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing, J Biol Chem 292 (2017) 19814–19825 10 1074 jbc m117 816645 [PMC free article] [Google Scholar] [220]





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