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  • Microdosimetry: Principles and applications - PMC
    In the y 2 f(y) vs log y representation (dose distribution), equal areas under the curve represent equal fractional doses The so-called “multi-event” distribution accounts for the fact that a given amount of energy can be deposited in a site by one or more concurrent events
  • Microdosimetry and detector responses. - NASA
    The field of study involving the evaluation of the energy imparted, ε, in microscopic volumes, typically a fraction of a micrometer to several micrometers across, is referred to as microdosimetry, and an understanding of the probability density distribution of ε for different radiations may be helpful in understanding the biological consequences
  • Microdosimetry - an overview | ScienceDirect Topics
    Microdosimetry is defined as a technique used to measure the stochastic distribution of energy deposited by radiation at microscopic sites, particularly in assessing energy transfer to very small volumes like cellular and subcellular structures
  • State-of-the-art and potential of experimental microdosimetry in ion . . .
    Recent clinical data suggests that local tumor control and normal tissue effects can be linked to macro-scopic and microscopic dosimetry parameters In particular, positive clinical outcomes have been corre-lated to the highest LET values in the density distribution, and there is no evident link to the saturation discussed above
  • Introductory Lecture on Microdosimetry - Indico
    We can define D(y) as the fraction of dose delivered by an event equal or less than y The dose probability density, called also weighted distribution, is: d(y)=∂D(y) ∂y The y mean-values define the “quality” of the radiation field for a given site size
  • ICRU Report 98, Stochastic Nature of Radiation Interactions . . .
    An understanding of the stochastic nature of energy deposition, or ionization, facilitates exploration of the consequences of irradiation and serves as a basis for modeling effects ranging from soft errors in microcomputers to mutations in biological systems and effectiveness of ion therapy
  • STOCHASTIC NATURE OF RADIATION INTERACTIONS: MICRODOSIMETRY
    3 5 Ionization Number in Defined Sites 3 6 Radial Distribution of Absorbed Dose 3 7 Presentation of Data 4 2 1 Wall Effect Due to Changes in Density 41 4 2 2 Wall Effect Due to Changes in Atomic Composition 42 5 Monte Carlo Simulations for Microdosimetry 44
  • Microdosimetry in ion-beam therapy for beginners
    The fundamental integral of microdosimetry • From the fundamental equation to the fundamental integral • To understand the process it is better to combine cumulative and density distributions • For what events the imparted energy is equal to or lower than 𝜺? ε= l · L
  • THE DOSIMETRY OF IONIZING RADIATION - LMU
    The deviations are most substantial for small volumes, for small doses, or for densely ionizing radiations; in many cases the energy imparted at a given absorbed dose can be zero or it can exceed the expectation value by orders of magnitude
  • Microdosimetry: Principles and applications
    information about the energy deposited in cellular and sub-cellular structures Fluctuations are more substantial for smaller volumes, smaller doses and for more densely ionizing radiations 2 Materials and methods 2 1 Formulations of microdosimetry





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