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tau    
n. 希腊字母第19字

希腊字母第19字

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  • New Biomarkers Catch Tau Before It Tangles | ALZFORUM
    Tau pathology in humans or animals, without fail, is made up of the hyperphosphorylated protein In AD tau is hyperphosphorylated sub-stoichiometrically at multiple sites by several combinations of protein kinases Six isoforms of tau in the human brain and hyperphosphorylation at multiple sites in AD generate numerous protein species
  • Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
    Tau, Incorporated A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains The degree of incorporation of each mutant into the growing fibrils (middle) is measured via FRET (right) [Courtesy of Vaquer-Alicea et al , Science Advances
  • ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
    The authors argue that tight binding between ApoE3Ch and tau that prevents fragmentation, plus weak binding between ApoE3Ch and lipoprotein receptor-related protein 1 (LRP1) and heparan sulfate proteoglycans, as reported previously, together prevent ApoE3Ch-bound tau from getting into neurons or microglia, stopping the spread of tau toxicity
  • Night-Night, Neurodegeneration: Sleep Aid Lulls Tau Pathology
    A different sleep drug, the GABA A modulator zolpidem, had no such effect, with mice bearing the full brunt of tau pathology (image below) Females, whose atrophy was milder, reaped little benefit from either therapy Goodnight, Degeneration: Vehicle-treated P301S E4 mouse show tau’s toll: swollen ventricles and a thinned hippocampus (left
  • Heavy Tau Snuffs Out Hippocampal Bursts | ALZFORUM
    Shushed by Tau Left: In patch-clamp setup, tau from AD brain is loaded into the recording pipette and diffuses into the CA1 neuron with which the pipette has made its seal Middle: Immunofluorescence image showing successful delivery of tau, with biocytin (green) marking the neuron, Tau-13 antibody staining infused tau (red)
  • Does the Brain Make Phospho-Tau to Fight Viruses?
    ICP27 Begets p-Tau In postmortem hippocampi from healthy controls (left), cells make little viral protein ICP27 (green) or p-tau (red) In hippocampi from mild AD brains (center), they make more of each, and these proteins occur together (arrows; overlay yellow) In advanced AD (right), ICP27 and p-tau are abundant and co-localized
  • Tau (AT8); Phospho Tau (Ser 202, Thr 205) | ALZFORUM
    Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease Recognizes paired helical filament (PHF) tau Phosphorylation at serine 202 and threonine 205 is required for recognition by AT8
  • Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
    In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of neurofibrillary tangles, with postmortem plaque and tangle load, and with cognitive test scores better than plasma total tau and neurofilament light, the currently available blood markers of neurodegeneration
  • Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
    By contrast, tau aggregates were neatly ordered, with uniform, evenly spaced fibrils arranged into bundles Many of these tau filaments resembled the paired helical filaments characteristic of AD But surprisingly, others looked more like fibrils found in people with chronic traumatic encephalopathy (CTE)
  • Could “Big Tau” Protect Brain Regions from Tangles?
    The new experimental findings strongly support predictions that the elongated projection domain of big tau, generated by exon 4a (with extra 250 amino acids), endows it with protective properties against the toxic misfolding, aggregation, and propagation of lower molecular weight tau that result in degeneration of the cognitive centers of the





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