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  • AP2 Adaptor Complex - an overview | ScienceDirect Topics
    AP2 comprises two large subunits of 100 kDa (α- and β2-adaptin), a medium 50 kDa subunit (μ2) and a small 17 kDa subunit (σ2) The 100 kDa α- and β2-adaptins comprise an N-terminal head domain linked by a flexible hinge to ‘ear’ or ‘appendage’ domains
  • Adaptins - Molecular Biology of the Cell
    The following sections describe the findings of a genome-wide survey for adaptins, GGAs, and stonins in these organisms COPI subunits are beyond the scope of this essay and are only discussed in relation to the adaptins
  • The structure and function of the β2‐adaptin appendage domain
    We demonstrate that the hydrophobic patch in the β2 appendage binds to a subset of DΦF W motif‐containing proteins that are bound by the α‐adaptin appendage domain (epsin, AP180, eps15) In addition to binding these proteins, the β2‐appendage domain alone shows significant direct clathrin binding
  • Calpain Hydrolysis of α- and β2-Adaptins Decreases Clathrin-dependent . . .
    Here we report the hydrolysis of the α- and β2-subunits of the tetrameric adaptor protein complex 2 by calpain Calcium-dependent α- and β2-adaptin hydrolysis was observed in several rat tissues, including brain and primary neuronal cultures
  • Adaptin - an overview | ScienceDirect Topics
    Adaptin refers to a protein complex that is essential for cargo transport between the trans-Golgi network and endosomal lysosomal compartments, playing a central role in the formation of clathrin-coated vesicles and the sorting of transmembrane proteins
  • AP1 2β-mediated exocytosis of tapetum-specific . . . - Oxford Academic
    These AP complexes consist of four subunits (adaptins): two large subunits (β1 and γ for AP-1, β2, and α for AP-2), a medium subunit μ, and a small subunit σ The general roles of some AP-1 and AP-2 adaptins in vegetative and reproductive development have been characterized in plants
  • Alpha adaptins show isoform-specific association with neurofibrillary . . .
    Here, we used multiple antibodies to investigate α-adaptin isoforms and their localization in human brains The specificities of ten different α-adaptin antibodies were evaluated using immunoblots after human AP2A1 and AP2A2 plasmid transfection in cultured cells





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